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Auton Lab (23andMe Research Institute)

Summary

The Auton Lab, led by Dr. Adam Auton at the 23andMe Research Institute, is a computational genetics group specializing in genome-wide association studies (GWAS) and pharmacogenetics. The lab leverages 23andMe's large database of genotyped participants and self-reported health surveys to identify genetic determinants of disease risk, phenotypic traits, and drug response. Their recent work has mapped genetic predictors of response and side effects for GLP-1 Receptor Agonists.

Research Focus

  • Pharmacogenetics: Identifying genetic variants that influence individual drug efficacy and adverse drug reactions (ADRs).
  • Large-scale GWAS: Designing and executing association studies on cohorts of hundreds of thousands to millions of research participants.
  • Electronic Health Record (EHR) Integration: Comparing self-report survey data with EHRs (e.g., via Apple HealthKit) to validate phenotype models.

Key Investigators

  • Adam Auton, D.Phil.: Vice President of Human Genetics and lead investigator at the 23andMe Research Institute.

Citations