AlphaFold 3
Summary¶
AlphaFold 3 extends protein structure prediction to joint complexes containing proteins, nucleic acids, small molecules, ions and modified residues. A diffusion-based coordinate generator enables one framework to model interaction types previously handled by specialized tools.
Capabilities¶
The reported evaluations showed improved accuracy for protein-ligand, protein-nucleic-acid and antibody-antigen interactions relative to selected contemporary baselines.[1] The broader molecular scope makes the system relevant to structural biology and drug discovery, while benchmark composition and data cutoffs remain important for interpretation.
See Protenix for an open-source reproduction based on the published architecture.