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Metrics

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Named metrics and statistical quantities used across the wiki.

Last updated: 2026-07-19

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Page Summary Tags Updated
Coefficient of Determination (R-squared) A statistical measure of how well genetic variants predict the variance in a molecular trait. reference, statistics, imputation, genetics 2026-07-19
Colocalization Posterior Probability (CLPP) A Bayesian metric used in genetic colocalization to determine if two traits share a common causal genetic variant at a specific genomic locus. reference, statistics, colocalization 2026-07-19
Credible Set Purity Definition and formula for calculating the purity of a credible set in statistical fine-mapping. reference, statistics, fine-mapping 2026-07-19
ePRS Penalization Framework Mathematical formulation of the external polygenic risk score (ePRS) framework including variant-specific penalty weights and loss function. reference, statistics, polygenic-risk-score, machine-learning 2026-07-19
Fractional Flow Reserve (FFR) A physiological metric representing the ratio of distal coronary pressure to aortic pressure during maximal hyperemia. cardiology, reference, physiology, hemodynamics 2026-07-19
Instantaneous Wave-Free Ratio (iFR) A vasodilator-free physiological metric measured during a specific diastolic period to assess coronary stenosis severity. cardiology, reference, physiology, hemodynamics 2026-07-19
Jaccard Similarity Coefficient A metric used to measure the similarity between two sets, often applied in comparing binary molecular fingerprints. reference, statistics, cheminformatics 2026-07-19
Learning Saturation Point A threshold-based metric indicating the minimum pretraining dataset size required to achieve near-optimal downstream model performance. reference, single-cell, foundation-model 2026-07-19
Local False Sign Rate (lfsr) Definition and formula for calculating the Local False Sign Rate (lfsr) to evaluate trait-specific significance in multitrait fine-mapping. reference, statistics, fine-mapping, multitrait 2026-07-19
Missense Score An ensembled score derived from 29 in silico deleterious prediction algorithms to assess missense variant pathogenicity. reference, statistical-genetics 2026-07-19
Normalized Connectivity Score (NCS) A metric developed by the Connectivity Map (CMap) project to quantify the similarity between a query gene expression signature and a drug perturbation profile. reference, connectivity-map, cmap, similarity-score 2026-07-19
Percentage BMI Change (ΔBMI%) A clinical metric used to measure weight loss or gain relative to baseline body mass index. reference, clinical, obesity, statistics 2026-07-19
Posterior Inclusion Probability (PIP) Definition and formula for calculating the Posterior Inclusion Probability (PIP) of a variant in statistical fine-mapping. reference, statistics, fine-mapping 2026-07-19
Posterior Probability of Full Colocalization (PPFC) Definition and formulation of the Posterior Probability of Full Colocalization (PPFC) used in multi-trait colocalization. reference, statistics, colocalization 2026-07-19
Ratio of Amino Acid Substitution (RAAS) The abundance ratio of a substituted amino acid peptide to its corresponding canonical base peptide. reference, proteomics, mass-spectrometry, biostatistics 2026-07-19
Reaction-Flux Genetic Interaction Statistical definition and interpretation of amplification or buffering between risk-allele dosage and predicted metabolic reaction flux. reference, biostatistics, metabolic-flux-analysis, cardiovascular-disease, genetics 2026-07-19
Steiger Filtering A statistical method to test and filter genetic instruments based on the direction of causal association between exposure and outcome. reference, statistical-genetics, mendelian-randomization 2026-07-19
Vendi Score A diversity evaluation metric for machine learning that measures the effective number of distinct elements in a dataset. reference, single-cell, transcriptomics 2026-07-19
Weighted Interval Score (WIS) A quantile-based proper scoring rule used to evaluate probabilistic forecasts. reference 2026-07-19

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