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Metallo Lab

Summary

The Metallo Lab is a systems medicine and metabolomics research laboratory led by Christian M. Metallo. The lab is jointly affiliated with the Molecular and Cell Biology Department at the Salk Institute for Biological Studies and the Department of Bioengineering at the University of California, San Diego (UCSD). Their research focuses on cellular metabolism, regulation of lipid homeostasis, and the development of stable isotope tracing methodologies such as Lipid-MFA.

Research Areas

The Metallo Lab's research combines stable isotope tracers, mass spectrometry, and mathematical modeling to study: - Lipid Homeostasis: Mapping the biosynthesis, elongation, and recycling of fatty acids, sphingolipids, and glycerolipids. - Tumor Metabolism: Investigating metabolic reprogramming in non-small cell lung cancer (NSCLC) and other malignancies, including the roles of the LKB1 and p53 tumor suppressors. - Methods Development: Designing computational models and tracing pipelines (e.g., Lipid-MFA in precision-cut tissue slices) to quantify intracellular fluxes.

Citations