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Randles Lab

Summary

The Randles Lab, led by Dr. Amanda Randles at Duke University, is a biomedical simulation and high-performance computing research group. The lab is renowned for developing personalized, image-based cardiovascular digital twins to model hemorheology and predict cardiovascular disease progression. A core development of the lab is HARVEY, a massive-scale fluid dynamics simulation platform that models blood flow from full-body arterial systems down to the level of individual cells.

Research Areas and Focus

The primary goal of the Randles Lab is to bridge the gap between high-performance computing (HPC) and clinical medicine. Key research thrusts include: * Vascular Digital Twins: Creating patient-specific models of the vasculature using clinical imaging (CT, MRI, angiography) to simulate blood flow dynamics, wall shear stress, and pressure gradients. * HARVEY Simulation Platform: Developing and optimizing the HARVEY parallel fluid dynamics solver to run on leadership-class supercomputers, enabling cellular-scale simulations of blood cells moving through complex geometries. * Digital Health and Cardiology: Integrating physiological simulations into clinical workflows to assist in diagnosis, risk stratification, and treatment planning for coronary artery disease.

Key Investigators

  • Amanda Randles, Ph.D.: Alfred Winborne and Victoria Stover Mordecai Professor of Biomedical Sciences in the Department of Biomedical Engineering, Duke University.

Citations

  • Randles A. Physiological Assessment of Coronary Artery Disease. N Engl J Med 2026;395:80-83. NEJMe2602134.pdf