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Sergouniotis Lab

Summary

The Sergouniotis Lab is a research group led by Dr. Panagiotis I. Sergouniotis, based at the University of Manchester and the Manchester Royal Eye Hospital. The lab focuses on ophthalmic genetics, genomic medicine, and the application of bioinformatics tools to analyze digital eye images and clinical datasets.

Research Focus

  • Ophthalmic Genetics: Investigating the genetic basis of inherited retinal dystrophies and other eye disorders.
  • Oculomics: Developing deep learning frameworks (such as Ret-AAE) and multi-omic pipelines to find associations between retinal imaging phenotypes and systemic cardiovascular or neurological diseases.
  • UK Biobank Studies: Leveraging large-scale cohorts like the UK Biobank to study the relationship between ophthalmic anatomy, genetics, and systemic health outcomes.

Citations

  • Julian, T. H. et al. (2026). Multi-omic analysis of deep learning-derived phenotypes links ophthalmic imaging to cardiovascular and neurological traits. Nature Cardiovascular Research, 5, 541–554. DOI: 10.1038/s44161-026-00815-5. Source paper: s44161-026-00815-5.pdf