Skip to content

Daemen Lab

Summary

The Daemen Lab, led by Dr. Joost Daemen at the Thorax Center, Erasmus MC in Rotterdam, is an interventional cardiology research group specializing in coronary physiology and coronary artery disease treatment. The lab focuses on evaluating novel diagnostic and therapeutic technologies, including wire-free angiography-derived fractional flow reserve (FFR) and drug-eluting stents. Their clinical trial work contributes significantly to validating computational methods that reduce the procedural burden of ischemic evaluations in the catheterization laboratory.

Research Areas and Focus

Key research topics of the Daemen Lab include: * Angiography-Based Physiology: Evaluating wire-free, computational models of coronary physiology (e.g., FFRangio and similar systems) to guide revascularization without hyperemic agents. * Clinical Trials in Interventional Cardiology: Design and execution of trials evaluating the safety, efficacy, and cost-effectiveness of new coronary imaging and physiological modalities. * Stent Technologies and Pharmacotherapy: Assessing clinical outcomes of drug-eluting stents and novel vascular devices.

Key Investigators

  • Joost Daemen, M.D., Ph.D.: Senior Interventional Cardiologist and Associate Professor at Thorax Center, Erasmus MC, Rotterdam.

Citations

  • Randles A. Physiological Assessment of Coronary Artery Disease. N Engl J Med 2026;395:80-83. NEJMe2602134.pdf
  • Daemen J, van der Eijk JA, Barbierato M, et al. Angiography-based physiology to guide coronary revascularization. N Engl J Med 2026;395:20-31.