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Gusev Lab

Summary

The Gusev Lab, led by Alexander Gusev, Ph.D., is based at the Dana-Farber Cancer Institute and Harvard Medical School and specializes in statistical genetics, computational biology, and genetic epidemiology. Its research focuses on the functional mechanisms linking genetic variation to complex diseases, particularly cancer susceptibility and clinical outcomes. The lab develops and applies methods for transcriptome-wide association studies (TWAS), eQTL analysis, and longitudinal EHR modeling such as ALADYNOULLI.

Research Focus

  • Transcriptome-Wide Association Studies: Pioneering methods to integrate eQTL reference panels with GWAS summary statistics to prioritize causal genes.
  • Cancer Susceptibility and Genomics: Investigating the germline genetic determinants of somatic cancer mutations, therapy response, and patient survival.
  • Clinical Informatics and EHRs: Developing machine learning and Bayesian methods to model longitudinal clinical events and phenotypes in large patient biobanks.

Citations