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Gerstung Lab

Summary

The Gerstung Lab (Division of AI in Oncology) is a computational biology and machine learning research group led by Dr. Moritz Gerstung at the German Cancer Research Center (DKFZ) in Heidelberg, Germany, with joint affiliations at the European Molecular Biology Laboratory (EMBL-EBI). The lab develops statistical models and deep learning frameworks to understand cancer evolution, analyze spatial transcriptomics and histopathology, and model multi-disease progression trajectories in human populations.

Research Focus

  • Disease Progression Modeling: Developing transformer-based architectures like Delphi-2M to learn lifetime disease progression paths and predict future morbidity risks from electronic health records.
  • Cancer Evolution and Dynamics: Modeling genomic alterations, subclonal architectures, and evolutionary paths in cancer development to predict clinical outcomes.
  • Computational Pathology: Applying deep learning models to process histopathological slides and discover spatial features linked to cancer genetics and therapy responses.

Key Investigators

  • Moritz Gerstung, Ph.D.: Division Head of AI in Oncology at DKFZ and former group leader at EMBL-EBI.

Citations